AOD-9604 calculator
AOD-9604 is a modified 16-amino-acid tail of growth hormone that was tested as an oral obesity drug by Metabolic Pharmaceuticals in the early 2000s. Six human trials covered 25 to 400 mcg/kg IV and 0.25 to 30 mg oral daily for up to 6 months; the drug was well tolerated but the weight-loss endpoint failed and development stopped.
- Frequency
- once daily
- Timing
- morning, fasted, 30 to 60 minutes before food or training
- Cycle
- 8 to 12 weeks, then 4 weeks off
- Route
- subcutaneous, abdomen; the trials were oral and IV
- Easy mix
- 5 mg + 2 mL = 2.5 mg/mL, so 250 mcg = 0.1 mL = 10 units, 300 mcg = 12 units and 500 mcg = 20 units. One vial is 20 doses at 250 mcg.
AOD-9604 units chart
5 mg vial. Rows are doses; columns show the units to draw on a U-100 syringe at each water volume.
| Dose | mL | U-100 units | Doses per vial |
|---|---|---|---|
| 100 mcg | 0.04 | 4 | 50 |
| 200 mcg | 0.08 | 8 | 25 |
| 250 mcg | 0.1 | 10 | 20 |
| 500 mcg | 0.2 | 20 | 10 |
| 1 mg | 0.4 | 40 | 5 |
| 2 mg | 0.8 | 80 | 2 |
| 2.5 mg | 1 | 100 | 2 |
| 5 mg | 2 | 200 | 1 |
Other mixes: 5 mg + 1 mL · 5 mg + 3 mL
About the AOD-9604 math
AOD-9604 is a synthetic peptide that corresponds to a modified fragment, residues 176 to 191, of a larger protein. It is listed as 5 mg vials of lyophilized powder. The example amount is 300 mcg, which does not divide evenly into 5 mg, so the arithmetic also shows what to do with the remainder. A 5 mg vial with 2 mL of bacteriostatic water is 2.5 mg/mL, or 2,500 mcg/mL. A 300 mcg draw is 0.12 mL, or 12 units on a U-100 syringe. Since 5,000 divided by 300 is 16.67, the vial gives 16 full draws and a final 200 mcg, which at this concentration is 8 units. With 1 mL in the vial the concentration is 5,000 mcg/mL and 300 mcg is 0.06 mL, or 6 units. With 2.5 mL it is 2,000 mcg/mL and the same draw is 0.15 mL, or 15 units. With 3 mL it is 1,667 mcg/mL (rounded) and 300 mcg is 0.18 mL, or 18 units. Every one of those volumes gives a whole unit mark for 300 mcg.
AOD-9604 questions
AOD-9604 dosage for weight loss?
Community use is 250 to 500 mcg subcutaneously once a day, fasted, for 8 to 12 weeks. The human trials gave 0.25 to 30 mg orally every day for up to 6 months and did not produce meaningful weight loss, so keep expectations low.
How many units of AOD-9604 is 300 mcg?
At 2.5 mg/mL (5 mg in 2 mL) 300 mcg is 12 units. 250 mcg is 10 units and 500 mcg is 20 units.
How many units is 300 mcg of AOD-9604 at 5 mg in 2 mL?
5 mg divided by 2 mL is 2.5 mg/mL, or 2,500 mcg/mL. 300 mcg divided by 2,500 mcg/mL is 0.12 mL. On a U-100 syringe 0.12 mL is 12 units.
How much bacteriostatic water for a 5 mg vial of AOD-9604?
Any volume the vial holds. 1 mL gives 5 mg/mL, 2 mL gives 2.5 mg/mL and 3 mL gives 1.67 mg/mL (rounded). A 500 mcg draw is 10 units, 20 units or 30 units at those three concentrations.
How many 250 mcg draws are in a 5 mg vial of AOD-9604?
5 mg is 5,000 mcg, and 5,000 divided by 250 is 20 draws. With 2 mL of solvent (2,500 mcg/mL) each 250 mcg draw is 0.1 mL, or 10 units.
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