PeptideCalculations
anti-inflammatory tripeptide (alpha-MSH fragment)

KPV dosage

KPV is the last three amino acids of alpha-MSH. In mice it calmed two models of colitis and reduced gut inflammation markers, and cell work shows it enters gut cells through the PepT1 transporter, which is why oral use is discussed. There are no human trials and no human dose. Community use is 200 to 500 mcg subcutaneously once or twice a day, or oral capsules in the low milligram range, for 2 to 6 weeks.

By the Peptide Calculations editors · Updated 2026-10-19 · Studied for gut inflammation and colitis in mice, skin inflammation, wound models

Dose
200 mcg to 500 mcg per injection
per injection · Commonly reported
How often
once or twice daily
any time; oral forms are taken before meals
How long
2 to 6 weeks
then reassess
Route
subcutaneous
abdomen; oral capsules also sold; topical for skin

1Dose ranges by source

RangePerBasisNote
200 mcg to 500 mcg per injectioninjectionCommonly reported
commonly reported
once or twice daily; 250 mcg twice a day is the common split
500 mcg to 1,000 mcg per daydayCommonly reported
commonly reported
upper range used during gut flares, 2 to 4 weeks

2Dose to units chart

5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL, so each unit on a U-100 insulin syringe holds 25 mcg.

DoseDraw (mL)UnitsDoses in vial
200 mcg0.08825
250 mcg0.11020
300 mcg0.121216
350 mcg0.141414
450 mcg0.181811
500 mcg0.22010
Open in the KPV calculatorFull 5 mg + 2 mL table

5 mg + 2 mL = 2.5 mg/mL, so 250 mcg = 0.1 mL = 10 units and 500 mcg = 20 units. A 10 mg vial + 2 mL doubles the strength: 250 mcg = 5 units.

3Commonly stacked with

LL-37 · 0.5 mg/mL to 1.6 mg/mL topical, twice weeklyKLOW blend · 2 mg to 4 mg of blend per injection (10 to 20 units at 20 mg/mL)

4Side effects

injection site rednessfew side effects reportedmild fatigue (reported)
Before you start. Human dosing is not established. Every efficacy result is from mice or cell culture, the 2008 colitis study being the main one. The microgram community dose is an extrapolation, not a scaled animal dose. Not medical advice. Talk to a clinician and start low.

Storage: lyophilized: fridge or freezer; reconstituted: fridge, use within 4 weeks (commonly reported)

5KPV dosage questions

What is the KPV peptide dosage?

There is no human-tested dose. Community use is 200 to 500 mcg subcutaneously once or twice a day for 2 to 6 weeks, with 250 mcg twice daily the most common split. Oral capsules are usually in the low milligram range.

How many units of KPV is 250 mcg?

With 5 mg in 2 mL (2.5 mg/mL), 250 mcg is 10 units. With 10 mg in 2 mL it is 5 units, so use 4 mL on a 10 mg vial if you want 10-unit draws.

Can KPV be taken orally?

Yes, it is sold as capsules and mouse work shows it is absorbed by gut cells through the PepT1 transporter. Oral doses people use are higher than injected ones because less reaches the bloodstream. No human study compares the routes.

Is KPV good for gut inflammation?

In mice with chemically induced colitis it sped recovery and reduced inflammation markers. That is the whole evidence base. People with inflammatory bowel conditions report trying it alongside, not instead of, their treatment.

6Sources

  1. Kannengiesser K et al., Inflamm Bowel Dis 2008, Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease (PubMed 18092346)
  2. Peptide Protocol Wiki, KPV dosing (community ranges, no human trials)

Educational summary of published labels, trials and commonly reported use. Not medical advice.

Brands we recommend for KPVIndependent. No affiliation with any brand, no affiliate links, no referral codes, no paid placements.
  1. 1Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
  2. 2Core Peptides long track record, public certificates, wide catalog
  3. 3Ascension Peptides public third-party testing, clear pricing