ACTH(4-10) analog nootropic, nasal · studied for memory and attention, recovery after stroke and head injury, stress tolerance

Semax dosage

Semax is a seven-amino-acid ACTH fragment sold as a nasal solution. In Russia it is a registered nootropic: the 0.1% drops deliver 50 mcg per drop and the labeled daily dose for memory and attention is 800 to 8,000 mcg, split over four applications. Outside Russia people run 200 to 600 mcg per application, two or three times a day, for 10 to 14 days. It is nasal, not injected. Mild nasal irritation is the only side effect on the label.

By the Peptide Calculations editors · Updated 2026-10-19

200 mcg to 2,000 mcg per application, 800 mcg to 8,000 mcg per dayper application

Basis: published study (Russian product label, Peptogen 0.1% nasal drops, 3 to 30 mcg/kg per dose). 2 to 3 drops per nostril, 4 times a day, 10 to 14 days; 50 mcg per drop

How often: 2 to 4 applications per day
When: daytime; the label puts the last application in the afternoon because it is mildly stimulating
How long: 10 to 14 days on the label, repeated if needed; community runs 2 to 4 weeks then a break
Route: intranasal, drops or spray, alternating nostrils
Storage: lyophilized: fridge or freezer; solution: fridge, dark, do not freeze (label: under 10 C); use a spray within about 4 weeks (commonly reported)

Dose ranges by source

Range	Per	Basis	Note
200 mcg to 2,000 mcg per application, 800 mcg to 8,000 mcg per day	application	published study (Russian product label, Peptogen 0.1% nasal drops, 3 to 30 mcg/kg per dose)	2 to 3 drops per nostril, 4 times a day, 10 to 14 days; 50 mcg per drop
400 mcg to 900 mcg per day	day	published study (Russian product label, mental fatigue and adaptation indication)	2 to 3 drops per nostril, 2 to 3 times in the first half of the day, 3 to 5 days
6,000 mcg to 12,000 mcg per day	day	published study (Russian product label, 1% solution, acute ischemic stroke, hospital use)	500 mcg per drop; 10 days; not a self-use dose
200 mcg to 600 mcg per application	application	commonly reported	2 to 3 times daily, usually from a 1 mg/mL spray

Semax dose to units chart

10 mg vial + 10 mL bacteriostatic water = 1 mg/mL (10 mcg per unit on a U-100 insulin syringe). 10 mg in 10 mL of bacteriostatic water = 1 mg/mL, the same 0.1% strength as the Russian drops. A standard pump sprays about 0.1 mL = 100 mcg, so 300 mcg = 3 sprays (or 6 drops at 50 mcg). Nasal, no syringe.

Dose	mL	Units (U-100)	Doses per vial
200 mcg	0.2	20	50
300 mcg	0.3	30	33
400 mcg	0.4	40	25
500 mcg	0.5	50	20
600 mcg	0.6	60	16
800 mcg	0.8	80	12
900 mcg	0.9	90	11
1 mg	1	100	10
2 mg	2	200	5

Different vial or water? Full 10 mg + 10 mL table or set your own numbers below.

Commonly stacked with

Selank 250 mcg to 300 mcg per application, about 900 mcg per day

Side effects

mild nasal irritation with long use
restlessness or trouble sleeping if used late in the day
headache (reported)

Before you start. The Russian label excludes pregnancy, children under 7, acute anxiety states and a history of seizures. Human evidence outside Russia is thin: a 24-person fMRI pilot and small post-stroke series. Do not use nasal decongestants at the same time (label). Not medical advice. Talk to a clinician and start low.

Semax dosage questions

How much Semax should I take?

The Russian label for the 0.1% drops is 2 to 3 drops per nostril (50 mcg per drop) four times a day for 10 to 14 days, which is 800 to 8,000 mcg a day depending on body weight. Most people outside Russia use 200 to 600 mcg per application, two or three times a day. Start at the low end.

Semax nasal spray dosage in sprays?

At 1 mg/mL (10 mg in 10 mL), a standard pump gives about 100 mcg per spray. 300 mcg is 3 sprays, split between nostrils. Count the sprays your bottle gives per mL before you trust the math.

Can you inject Semax?

The registered product is nasal only, and all the Russian dosing data is nasal. There is no published human injection dose, so there is nothing to copy. Keep it nasal.

How long does a Semax cycle last?

The label courses are 3 to 14 days, repeated if needed. Community use is usually 2 to 4 weeks, then a break of similar length. Long daily use is what causes the nasal irritation the label mentions.

Sources

Brands we recommend for Semax. We are independent and have no affiliation with any brand: no affiliate links, no referral codes, no paid placements. These are the suppliers whose testing and certificates hold up when we check them.

Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
Core Peptides long track record, public certificates, wide catalog
Ascension Peptides public third-party testing, clear pricing

This page is an educational summary of published labels, trials and commonly reported use. It is not medical advice and does not replace a clinician.