PeptideCalculations
GHRH analog, short acting

Sermorelin dosage

Sermorelin is the first 29 amino acids of natural GHRH. It was FDA approved as Geref for childhood growth hormone deficiency at 30 mcg/kg at bedtime and as a diagnostic test, then withdrawn in 2008 for manufacturing reasons, not safety. Today it is compounded and sold as a research peptide. Adults commonly inject 200 to 300 mcg under the skin at bedtime, 5 nights a week, for 3 to 6 months.

By the Peptide Calculations editors · Updated 2026-10-19 · Studied for growth hormone deficiency in children (former FDA approval), pituitary function testing, adult GH support and sleep (compounded off-label use)

Dose
30 mcg/kg
per day, at bedtime · FDA label
How often
once daily
fasted, 30 minutes before bed, at least 90 minutes after food
How long
3 to 6 months
then reassess; the pediatric label use ran 12 months or more
Route
subcutaneous
abdomen or thigh; rotate sites

1Dose ranges by source

RangePerBasisNote
30 mcg/kgday, at bedtimeFDA label
FDA label
historical Geref pediatric dose for growth hormone deficiency; 1 mcg/kg IV for the diagnostic test
200 mcg to 300 mcgday, at bedtimeCommonly reported
commonly reported
adult off-label and research-vial use; also the range on the RxList label summary

2Titration schedule

Step up on this schedule. Stay a step longer if side effects are rough.

WeeksDose
1-2100 to 200 mcg at bedtime
3 onward200 to 300 mcg at bedtime

3Dose to units chart

2 mg vial + 1 mL bacteriostatic water = 2 mg/mL, so each unit on a U-100 insulin syringe holds 20 mcg.

DoseDraw (mL)UnitsDoses in vial
25 mcg0.0131.380
30 mcg0.0151.566
Open in the Sermorelin calculatorFull 2 mg + 1 mL table

2 mg + 1 mL = 2 mg/mL, so 200 mcg = 0.1 mL = 10 units; 300 mcg = 15 units. A 5 mg vial with 2.5 mL gives the same 2 mg/mL.

4Commonly stacked with

Ipamorelin · 200 mcg to 300 mcgGHRP-2 · 1 mcg/kg

5Side effects

injection site pain, redness or swellingflushingheadachedizzinesshyperactivity or restlessnesstrouble swallowing (rare, on the label)water retention
Before you start. The only label dose is for children by body weight; adult 200 to 300 mcg dosing is compounding-pharmacy and community practice. Raising GH and IGF-1 argues for caution with any cancer history, and it does little if the pituitary cannot respond. Food, especially before bed, blunts it. Not medical advice; start low and talk to a clinician.

Storage: lyophilized: fridge; reconstituted: fridge, commonly used within 4 weeks (commonly reported); the Geref label said refrigerate and use reconstituted vials promptly

6Sermorelin dosage questions

How much sermorelin should I take?

Adults commonly inject 200 to 300 mcg at bedtime, 5 nights a week. The old FDA label was 30 mcg/kg nightly for children, which would be about 2 mg for a 70 kg adult, but nobody uses that in practice. On a 2 mg vial in 1 mL, 200 mcg is 10 units.

How many units of sermorelin is 200 mcg?

With 2 mg reconstituted in 1 mL you have 2000 mcg per mL, so 200 mcg is 0.1 mL, which is 10 units on a U-100 syringe. 300 mcg is 15 units. With 5 mg in 2.5 mL the numbers are the same.

Is sermorelin FDA approved?

It was, as Geref, for childhood growth hormone deficiency and as a diagnostic test. The brand was withdrawn in 2008 for manufacturing reasons, so there is no approved product today. Sermorelin you get now is compounded or sold as research material.

Sermorelin vs CJC-1295?

They are nearly the same molecule: CJC-1295 no DAC is sermorelin with four amino acid swaps that extend its half-life from minutes to about half an hour. Doses overlap at 100 to 300 mcg. Sermorelin has the regulatory history; CJC-1295 is cheaper per effective dose, by user report.

7Sources

  1. RxList, Sermorelin acetate (Geref) clinical pharmacology and dosage summary
  2. Peptide Protocol Wiki, Sermorelin overview and protocol quick reference

Educational summary of published labels, trials and commonly reported use. Not medical advice.

Brands we recommend for SermorelinIndependent. No affiliation with any brand, no affiliate links, no referral codes, no paid placements.
  1. 1Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
  2. 2Core Peptides long track record, public certificates, wide catalog
  3. 3Ascension Peptides public third-party testing, clear pricing