synthetic pineal tetrapeptide (Khavinson bioregulator) · studied for aging markers, melatonin rhythm, telomerase activity in cells

Epitalon dosage

Epitalon is a four-amino-acid synthetic version of the pineal extract epithalamin. The human data is Russian and uses the extract, given as 10 mg intramuscular courses to elderly cardiac patients over years. Community protocols copy the number: 5 to 10 mg a day, subcutaneous, for 10 to 20 days, once or twice a year. There is no dose-finding study in people and no Western trial.

By the Peptide Calculations editors · Updated 2026-10-19

10 mg per injection, courses of 5 injectionsper injection

Basis: published study (Korkushko, Khavinson et al. 2011, Bull Exp Biol Med; epithalamin extract, intramuscular, 6 courses over 3 years, 39 vs 40 patients). every 3 days within a course, as reported in secondary summaries of the Khavinson protocols; the extract is not identical to synthetic epitalon

How often: once daily during a course
When: evening is common because of the melatonin link; the Russian courses were daytime clinic injections
How long: 10 to 20 days, then off for 4 to 6 months; 1 to 3 courses a year
Route: subcutaneous (community) or intramuscular (Russian studies)
Storage: lyophilized: fridge or freezer; reconstituted: fridge, use within 4 weeks (commonly reported)

Dose ranges by source

Range	Per	Basis	Note
10 mg per injection, courses of 5 injections	injection	published study (Korkushko, Khavinson et al. 2011, Bull Exp Biol Med; epithalamin extract, intramuscular, 6 courses over 3 years, 39 vs 40 patients)	every 3 days within a course, as reported in secondary summaries of the Khavinson protocols; the extract is not identical to synthetic epitalon
5 mg to 10 mg per day	day	commonly reported	10 to 20 days, repeated 1 to 2 times a year; 1 to 5 mg daily is the conservative variant

Epitalon dose to units chart

50 mg vial + 2.5 mL bacteriostatic water = 20 mg/mL (200 mcg per unit on a U-100 insulin syringe). 50 mg + 2.5 mL = 20 mg/mL, so 10 mg = 0.5 mL = 50 units and 5 mg = 25 units. A 50 mg vial is one 5-day course at 10 mg or a 10-day course at 5 mg. A 10 mg vial + 1 mL gives the same 10 mg/mL math per unit doubled: 5 mg = 50 units.

Dose	mL	Units (U-100)	Doses per vial
5 mg	0.25	25	10
10 mg	0.5	50	5

Different vial or water? Full 50 mg + 2.5 mL table or set your own numbers below.

Commonly stacked with

Pinealon 10 mg to 20 mg per day

Side effects

injection site redness
vivid dreams or sleep changes (reported)
headache (reported)
few side effects reported overall

Before you start. No human dose-finding, pharmacokinetic or placebo-controlled Western trial exists for synthetic epitalon. The 10 mg figure comes from the extract studies by the inventing group, not from independent work. The telomerase data is cell culture. Not medical advice. Talk to a clinician and start low.

Epitalon dosage questions

What is the epitalon dosage protocol?

The common protocol is 5 to 10 mg a day subcutaneously for 10 to 20 days, run once or twice a year. The Russian extract studies used 10 mg intramuscular injections in short courses repeated over years. Nothing in people compares doses.

How many units is 10 mg of epitalon?

At 20 mg/mL (50 mg in 2.5 mL) 10 mg is 50 units. At 10 mg/mL (10 mg in 1 mL or 20 mg in 2 mL) 10 mg is a full 100 units. Pick the water volume that keeps the draw under 50 units.

How often can you cycle epitalon?

Community practice is one 10 to 20 day course every 4 to 6 months, so 2 or 3 a year. The 2011 Russian study gave 6 courses over 3 years. Nobody has tested continuous use.

Is epitalon the same as epithalamin?

No. Epithalamin is a pineal gland extract used in the Russian clinical work. Epitalon is the synthetic tetrapeptide modeled on it. The human mortality and melatonin data is for the extract, which is why community dosing is an extrapolation.

Sources

Brands we recommend for Epitalon. We are independent and have no affiliation with any brand: no affiliate links, no referral codes, no paid placements. These are the suppliers whose testing and certificates hold up when we check them.

Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
Core Peptides long track record, public certificates, wide catalog
Ascension Peptides public third-party testing, clear pricing

This page is an educational summary of published labels, trials and commonly reported use. It is not medical advice and does not replace a clinician.