growth hormone secretagogue (ghrelin receptor agonist) · studied for growth hormone release, body composition, sleep, recovery (user reports); post-operative gut motility (early trial)

Ipamorelin dosage

Ipamorelin is a 5 amino acid GH secretagogue described in 1998 as the first one that releases growth hormone without much cortisol or prolactin. It was never approved and never finished late-stage trials. Users commonly inject 200 to 300 mcg under the skin once or twice daily, fasted, most often at bedtime, for 8 to 12 weeks, and usually pair it with CJC-1295 without DAC. Human dosing is not established.

By the Peptide Calculations editors · Updated 2026-10-19

200 mcg to 300 mcgper dose, 1 to 2 times daily

Basis: commonly reported. the standard community protocol, bedtime fasted; 100 to 200 mcg each when combined with CJC-1295 no DAC

How often: once or twice daily, some users 3 times
When: fasted, 30 minutes before bed; morning and post-workout as extra doses; avoid food 1 to 2 hours before and 30 minutes after
How long: 8 to 12 weeks, often 5 days on and 2 off, then 4 weeks off
Route: subcutaneous, abdomen
Storage: lyophilized: fridge or freezer; reconstituted: fridge, commonly used within 4 weeks (commonly reported)

Dose ranges by source

Range	Per	Basis	Note
200 mcg to 300 mcg	dose, 1 to 2 times daily	commonly reported	the standard community protocol, bedtime fasted; 100 to 200 mcg each when combined with CJC-1295 no DAC
100 mcg to 200 mcg	dose	commonly reported	the lower range cited by other community references, sometimes called the saturation dose

Titration schedule

Step up on this schedule; stay a step longer if side effects are rough.

Weeks	Dose
1	100 to 200 mcg at bedtime
2-12	200 to 300 mcg at bedtime, optional second dose

Ipamorelin dose to units chart

5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL (25 mcg per unit on a U-100 insulin syringe). 5 mg + 2 mL = 2.5 mg/mL, so 250 mcg = 0.1 mL = 10 units; 200 mcg = 8 units, 300 mcg = 12 units. A 10 mg vial with 4 mL gives the same numbers.

Dose	mL	Units (U-100)	Doses per vial
100 mcg	0.04	4	50
200 mcg	0.08	8	25
250 mcg	0.1	10	20
300 mcg	0.12	12	16

Different vial or water? Full 5 mg + 2 mL table or set your own numbers below.

Commonly stacked with

CJC-1295 (no DAC) 100 mcg to 200 mcg
CJC-1295 (DAC) 30 mcg/kg to 60 mcg/kg
Sermorelin 30 mcg/kg

Side effects

head rush or flushing right after injecting
headache
water retention
mild hunger
injection site redness
tingling hands
vivid dreams

Before you start. Human dosing is not established; the ranges are user protocols. Ipamorelin has only early-phase human data, and the FDA has recommended against including it in compounded drugs. Raising growth hormone raises IGF-1, so people with active cancer or a cancer history, and anyone with diabetes, should be careful. Not medical advice; start low and talk to a clinician.

Ipamorelin dosage questions

How much ipamorelin should I take?

There is no established human dose. The commonly reported range is 200 to 300 mcg under the skin once or twice daily, fasted, with the bedtime dose considered the most important. On a 5 mg vial in 2 mL that is 8 to 12 units.

How many units of ipamorelin is 200 mcg?

With 5 mg in 2 mL you have 2500 mcg per mL, so 200 mcg is 0.08 mL, which is 8 units on a U-100 syringe. 250 mcg is 10 units. If you used 1 mL of water, halve those.

When should I take ipamorelin?

Fasted, right before bed, is the commonly reported timing because the natural GH pulse happens in early sleep and food blunts the response. If you take a second dose, morning fasted or after training is typical. Keep 1 to 2 hours between food and the shot.

Ipamorelin vs sermorelin, what is the difference?

Sermorelin is a GHRH analog that tells the pituitary to make a pulse; ipamorelin is a ghrelin mimic that amplifies it through a different receptor. That is why people stack ipamorelin with CJC-1295 no DAC or sermorelin rather than choosing. Doses are similar, 200 to 300 mcg.

Sources

Brands we recommend for Ipamorelin. We are independent and have no affiliation with any brand: no affiliate links, no referral codes, no paid placements. These are the suppliers whose testing and certificates hold up when we check them.

Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
Core Peptides long track record, public certificates, wide catalog
Ascension Peptides public third-party testing, clear pricing

This page is an educational summary of published labels, trials and commonly reported use. It is not medical advice and does not replace a clinician.